|
rs1799782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.
|
23534771 |
2013 |
|
rs7574920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the same GPX1 polymorphisms and XDH rs7574920 were found to significantly modify the association between cumulative lead exposure and meningioma.
|
19505917 |
2009 |
|
rs730882035
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe a Sicilian girl with type 2C VHL who showed the apparently de novo mutation R161Q in association with an extra-axial supratentorial frontal meningioma, which can be included as a characteristic sign in VHL.
|
17102087 |
2006 |
|
rs768803947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A tumor-specific missense mutation as a result of an A-to-G transition with an Asn204Ser change was found in one meningioma that nevertheless retained the normal allele.
|
11520574 |
2001 |
|
rs2736100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
rs202247756
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We combined genome-wide linkage analysis and exome sequencing, and we identified in suppressor of fused homolog (Drosophila), SUFU, a c.367C>T (p.Arg123Cys) mutation segregating with the meningiomas in the family.
|
22958902 |
2012 |
|
rs9420907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
rs699473
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed increased risk of glioma (odds ratio [OR](CT/CC)=1.3; 95% confidence interval [95% CI], 1.0-1.7) and meningioma (OR(CT/CC)=1.7; 95% CI, 1.1-2.7) with the C variant of SOD3 rs699473.
|
18682580 |
2008 |
|
rs121918347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A subset of meningiomas lacking NF2 alterations harbored recurrent oncogenic mutations in AKT1 (p.Glu17Lys) and SMO (p.Trp535Leu) and exhibited immunohistochemical evidence of activation of these pathways.
|
23334667 |
2013 |
|
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls.
|
20723250 |
2010 |
|
rs854560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls.
|
20723250 |
2010 |
|
rs25406
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).
|
20150366 |
2010 |
|
rs150766139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The carrier of c.268C>T (p.Q90*) and 550-1G>A was diagnosed with CRC and meningioma at ages 37 and 45 respectively, being reclassified as attenuated adenomatous polyposis after the cumulative detection of 26 adenomas.
|
31227763 |
2019 |
|
rs121434259
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs587776563
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1805794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The NBN rs1805794 minor allele variant was associated with decreased meningioma risk (P(trend) .006).
|
20150366 |
2010 |
|
rs10936599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
rs3219466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).
|
20150366 |
2010 |
|
rs1801394
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, we found that MTRR A66G (rs1801394) variant genotypes was associated with increased risk of meni</span>ngioma and glioma (G vs. A: OR=1.11, P=0.020; GG vs. AA+AG: OR=1.17, P=0.043; GG vs. AA: OR=1.22, P=0.023).
|
28915669 |
2017 |
|
rs1801394
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The current meta-analysis firstly provides evidence that the MTHFR C677T polymorphism may modify the risk for brain tumors, particularly meningioma.
|
23846816 |
2013 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.
|
16821630 |
2006 |
|
rs1801131
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
|
rs1801131
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.
|
28915669 |
2017 |
|
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.
|
28915669 |
2017 |